A parent who possesses a balanced translocation a chromosome rearrangement with no extra genetic material from chromosome 21 can pass the translocation to an offspring.
Hues-1 and Hues-15 were found to be karyotypically normal, whereas Hues-3 (subclone 52) has a gain of material from chromosome 17 (82%).
Loss of material from chromosome 4 and 13 and gain of 2p were more frequently found in the invasive components.
Loss of material from chromosome arm 11p, and gains of chromosome 7 and chromosome arm 1q seem to be early but secondary changes.
The gain of material from chromosome arm 12p is a central feature for TGCT (309) and is also common among DGs.
Since then, loss of genetic material from chromosome 22 has been the most consistent aberration, observed in up to 70% of tumors [ 6, 7].
In addition, numerous complex Chr17 derivatives containing material from chromosomes 8, 16, 19 and 22 were observed.> -wrap-foot> der = derivative chromosome; dic = dicentric chromosome.
These included gains affecting chromosomes 3q, 8q, 5p, 7q, 12p and 11q and deletion of material from chromosomes 3p, 11q, 4p, 5q, 8p, 10q, 13q and 21.
Reported frequent aberrations common to both SE and NS include gain of material from chromosomes 1, 7, 8, 17, 21 and X and loss of material from chromosomes 4, 5, 11, 13, 18 and Y van Echtenn et al, 1995; Korn et al, 1996; Mostert et al, 1996; Sandberg et al, 1996; Summersgill et al, 1998a, 1998b; Kraggerud et al, 2002; von Eyben et al, 2004).
Alkylator-associated t-AML has a latency of 5 7 years, is often preceded by a myelodysplastic phase (t-MDS) and is frequently associated with loss of material from chromosomes 5 and/or 7 in humans.
The gain of 12p was identified in all cases and additional material from chromosomes 7 and 8 was found in over 70% of cases, in keeping with previous analyses.
