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The polymeric surface prepared with 1 60 (mol/mol) of MePEG-GMA to DMAEMA induces neuronal regenerative responses similar to that on poly-l-lysine, a very common benchmark material for nerve cell cultures.
The current study follows the aim to establish polysialic acid (polySia), a homopolymer of α2,8-linked sialic acid residues, as a novel, biocompatible, and bioresorbable material for nerve tissue engineering.
Collectively, these data indicate that silk fibroin has good biocompatibility with DRG and is also beneficial to the survival of Schwann cells without exerting any significant cytotoxic effects on their phenotype or functions, thus providing an experimental foundation for the development of silk fibroin as a candidate material for nerve tissue engineering applications.
These results suggest that biomaterial surface topography or other methods of altering the orientation of cells may be used to engineer orientation into the secreted extracellular matrix and as such may be a potential strategy for developing organized cell-derived matrix as a bridging material for nerve repair or other regenerative applications.
The usage of spider silk fibers as guidance material for nerve regeneration is a novel and unique idea.
Several mechanisms including axonal sparing, sprouting and plasticity associated with novel polysynaptic pathways, recruitment of endogenous SCs and remyelination have been suggested to contribute to improvement in function in large nerve defects bridged with guidance material for nerve regeneration.
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The design and testing of materials for nerve regeneration, to repair damage caused by illness or accident, is an active area of research.
These findings suggest that MWCNTs-coated nanofibrous scaffolds may be alternative materials for nerve regeneration and functional recovery in neural tissue engineering.
In this study we tested two types of poly l/dl lactic acid (PLA95/5 and PLA70/30), a biodegradable material permissive for neural cell adhesion and growth, as materials for nerve regeneration.
Scaffolds and tubes are used as guidance materials for nerve grafts.
In a study that aimed at applying CNTs to regenerative medicine, CNTs were found to work excellently as scaffold materials for nerve and bone tissue regeneration.
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