These novel clusters are very interesting and they are valuable materials for discovery of new functions.
Urine post-DRE is achievable for all men suspected for prostate cancer; thus it represents a minimally invasive and challenging starting material for biomarker discovery.
There is a growing consensus that the CSF is the best material for biomarker discovery and for understanding the ongoing pathological processes associated with neurodegeneration [ 38, 39].
Voided urine obtained immediately after DRE is greatly enriched in prostatic cells (about 80%) and thus represents a challenging starting material for biomarker discovery in oncological research.
A successful study of this type would more clearly suggest that buccal cells have efficacy as source material for biomarker discovery or in a gene expression monitoring system than earlier studies.
Massive sequencing of cDNA libraries will continue to produce raw materials for gene discovery, identification of polymorphisms (SNPs, EST-SSRs, INDELs, etc).
Nearly all previous studies of metagenomic sequencing of viruses from human clinical material for detection and discovery have employed pyrosequencing [6], [16], [17], [18], [19], [20], [21], [22], [32], [42], [43].
Together with recent innovations in digital publishing, a renewed interest in the development of standards for engineering materials data offers new prospects for discovery, exchange, and reuse of engineering materials data.
Computation-driven catalyst design is reviewed and a new platform for discovery of materials with emergent behavior is introduced.
We thank members of the 1996 expedition for discovery of the material, Q. Cao and R. Masek for fossil preparation, E. Fitzgerald and T. Keillor for molding and casting, C. Straus for CT-scanning of fossil bones, and C. Abraczinskas for specimen drawings and executing final drafts of reconstructions.
