However, a comprehensive assessment of potential biological effects induced by GRM is currently hardly feasible to accomplish due to the lack of well-defined GRM materials and realistic exposure data.
According to the Scientific Panel on Food Additives, Flavourings, Processing Aids, and Materials in Contact with Food (AFC), exposure data is scarce and limited to exposure via food, although other sources may contribute significantly [ 13].
We present these data-driven results with the new air pollutant exposure data primarily in the Supplemental Material, Table 3 (doi:10.1289/ehp.0901407).
A more detailed description of the choice of New Jersey COH and comparison with the other exposure data is provided in the Supplemental Material (doi 10.1289/ehp.1002981).
Individual indicators of exposure to traffic were derived from the most recent road networks for Europe and from locally available traffic intensity data (for detailed description, see Supplemental Material, "Exposure assessment methods").
The data on the human exposures to man-made vitreous fibers are much more complete than the data on asbestos exposure, while exposure data on other man-made fibrous materials are lacking.
Case control sample sizes taking into account LIBCSP subject selection procedures, participation rates, and vehicular traffic exposure data availability are presented in the Supplemental Material, Table S1.
However, as systemic exposure data (i.e. blood concentration/time data of test material or metabolites) in humans will not be available for agrochemicals, an in vitro approach must be taken.
Human studies often suffer from either inadequate exposure data or exposure to a wide variety of materials, so that attribution of effects to styrene exposure is impossible.
Animal data are deemed not relevant, human data not representative, and exposure data not reliable".
