The specificity of the CRISPR/Cas9 system thus matches the specificity of previously described zinc-finger nucleases19 and TALENs24,25 on the whole-genome scale.
Initially, 39 self-report items were developed in order to match the specificity of aggressive behavior among children that commonly takes place in the school context.
Accessible peptides that match the specificity of these motif-binding domains are continuously created and destroyed by mutations in rapidly evolving disordered regions, creating a dynamic supply of new interactions that may have advantageous phenotypic novelty.
Indeed, when the urine metabolomics diagnostic test was set to match the specificities of the fecal-based tests (Table 3), its sensitivity for detecting colonic adenomas was still higher than that of the fecal-based tests.
Finally, in an antibody-dependent opsonophagocytic assay, S. pneumoniae expressing a PspC variant matching the antibody specificity was killed efficiently.
The 1-day filter, while closely matching the nominal specificity, performed poorly in terms of maximizing the sensitivity to detect an outbreak signature.
In contrast, chicken TAP genes are highly polymorphic, with each haplotype encoding a TAP molecule with a peptide-translocation specificity matching the peptide-binding specificity of the dominantly expressed class I molecule encoded by the BF2 gene, with the BF1 gene expressed poorly or not at all (Wallny et al., 2006; Shaw et al., 2007; Walker et al., 2011).
Before matching, the accuracy and specificity of NM-NBI were superior to those of CE-Iodine (P=0.03 and P=0.01).
For Cas1, the reaction is strongly sequence dependent with the specificity matching the predicted integration site 1 for both E. coli and Sulfolobus solfataricus Cas1, and does not require Cas2.
Antigenic diversity and heterogeneity of FMDV require the periodic updating of multivalent vaccine formulations to match the antigenic specificity of the vaccine with that of the viruses circulating in the field.
