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Vert and Kanehisa [ 16] used kernel methods to identify expression patterns that characterize gene sets matching pathways in a given network.
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A list of identified proteins was entered into Pathway Studio in order to determine matching pathways for each protein.
To match pathway mentions in text, we employed soft dictionary matching as term variations often cause exact string matching to fail [ 24].
Another interesting example is pathway 20, which is found to match pathway sce03020 'RNA polymerase' in KEGG, with an ARI score of 0.95.
Biological pathways identified by DAVID/EASE analysis using a list of 423 tissue-selective genes matched archetypal pathways in the corresponding human or mouse tissue.
cThe number of genes matching KEGG pathways.
Differences seen between enriched pathways in matched tumors could be attributed to copy number differences seen between the two samples due to large numbers of of genes being found in regions of difference.
A major change in paradigm for cancer treatment has been to try and fit the therapy in the individual to match the oncogenic pathway in the cancer.
A total of 12 candidate genes for PAL, C4H, p-coumaroyl ester 3′-hydroxylase (C3'H), 4-coumarate CoA ligase (4-coumarate CoA2, fligasene 3-hydroxylase (F3H1, F3H2), F3'H, dihydroflavonol 4CLeduCHS1es (DFR), anthoCHS2idin synthase (ANS) and ANR with annotations matching enzymes in the Pflavanone leading to ECG and mangiferin biosynthesis were identified.
Path matching and graph matching to query certain metabolic pathways in an input graph was provided by Yang and Sze (2007).
The complete results are reported in supplemental materials [protein domain matches in additional file 3; pathways in additional file 4].
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