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While the use of the "Longenity Project" spouse control group dramatically enhances the reliability of matching of cases and controls in terms of population stratification, the same approach potentially introduces a different potential source of bias.
Identical analyses with age strata of 3 and 5 years for matching of cases and controls gave similar results.
However, it requires careful avoidance of false-positives, and matching of cases identified by both networks, which was achieved by the home visit.
These are crude ORs without matching of cases and controls, so the E-R patterns are an approximation of actual trends.
To test whether matching of cases and controls based on sire was successful, breed-specific genomic kinship among animals was computed based on identity-by-state of SNP genotypes.
With regard to behaviour and occupation, age and sex were considered the two most important confounders and were eliminated by matching of cases and controls at the design stage of the study.
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Because of the limited retrospective accessibility to adequately phenotyped samples with known pre- and post-infection status, our population sizes did not allow matching of case and control samples by breed.
An example is the matching of case, number, and gender between nouns and adjectives.
Third, the matching of case-patients and controls by location could have selected for similar behavior among them, and thus falsely reduced the observed strength of associations of possible risk factors.
Conditional logistic regression to adjust for the matching of case subjects and control subjects was used to determine the independent effect of the principal components and the composite score on the progression of CAC.
It is expected that many rare variants will have a very restricted geographic distribution (51, 52) so that careful matching of case and control ancestries is likely to be extremely important.
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