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Finally, matching normal tissue is not necessary for methylation assays, in contrast to LOH.
Tumour and matching normal tissue was available from 48 NSCLC patients in the independent series.
When matching normal tissue was not available, a DNA mixture from several normal breast tissues was used as a control.
We isolated a differentially expressed sequence (F1. 4) in a DD analysis of RNA from HNSCC and matching normal tissue.
Hematoxylin and Eosin-stained sections from paraffin-embedded tissue blocks were reviewed by an anatomical pathologist (WAC) for tumour and matching normal tissue specimens.
The specificity of SNaPshot genotyping was evaluated by analysis of primary tumour samples and matching normal tissue from the same individual.
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For this purpose, additional frozen tissues of pancreatic cancers were collected without matching normal tissues.
There were 65 tumors with matching normal tissues adjacent to the tumors.
Genome-wide transcriptomic profiles were obtained for 53 primary OTSCCs and 22 matching normal tissues.
Consequently, even though many gene promoters become hypermethylated, overall cancers are hypomethylated compared with matching normal tissues.
Kenneth Kinzler and colleagues report exome sequencing of ten hepatocellular carcinoma tumors and matched normal tissue.
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