However, as the Reviewer correctly points out, none of our point mutants match in severity the effect on dynamics or function of either GSK3 inhibition or deletion of either R2 or B. We thus have tried to make this clearer in both the Results and Discussion.
While we did not control for volume of resuscitation in our analysis, matching by severity of illness (APACHE II or ISS scores) should imply a similar resuscitation burden between and across cohorts, thereby minimizing the potentially confounding effects of acute fluid loading.
The two groups were matched in terms of depression severity.
The HES supplementation group was compared with a group of patients from the same center matched in age, sex and severity of burns at baseline.
There is however no evidence on the stability of fat-soluble vitamins in transfused blood and matching by trauma severity (ISS) would plausibly suggest similar transfusion schedules.
Patients in two groups were matched in terms of age, gender, severity of knee arthrosis and pre-treatment WOMAC scores.
In contrast to these findings, Hurst et al [ 8] observed a similar rate of adverse events in a cohort of patients who were stationary in the ICU and matched for severity of illness [Acute Physiology and Chronic Health Evaluation APACHE) II score] and age with the transport group (60 versus 66%).
There were significant differences in mortality and ICU stay between the ICUs in clinical hospitals (28.7%; 8.3 ± 0.9 days) compared with the ICUs in small towns (55.5%; 9.1 ± 1.3 days) and large towns (31.8%; 8.6 ± 1.1 days), which did not match the differences in severity of disease measured by APACHE II and SOFA scores.
The patients were matched for severity of neurological deficits, and ranged in age from 18 to 82.
In particular, the patients were well matched for severity of illness and background comorbidities as assessed by their ASA scores.
Control and experimental groups were evenly matched in terms of their baseline characteristics, disease severity, type of organ dysfunction, and source of infection.
