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Despite matching for baseline best corrected visual acuity (BCVA) and duration of disease, substantial heterogeneity existed between anti-VEGF RCTs.
Despite the independent association between RBP4CAD and CAD diagnosis, the absence of matching for baseline characteristics may weaken our conclusions.
The authors performed covariate matching for baseline HbA1c and duration of diabetes which lead to balanced group numbers, apart from the age difference, which was adjusted for in multivariate comparisons.
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The trauma cohort was well matched for baseline and secondary characteristics.
While the treatment and placebo groups appeared to be well matched and blinding appeared to be adequate in this study, we cannot be certain that the groups were well matched for baseline performance at the 400-m run.
Cases and controls were well matched for baseline characteristics but differed on other important characteristics such as presence of diabetes, use of minute ventilation and risk factors for ALI/ARDS (Table 1).
Efavirenz-treated controls were matched for baseline characteristics to the maraviroc-treated patients selected for this substudy.
The groups were matched for baseline maternal characteristics, maternal glycemia, and pregnancy outcomes.
The placebo and fenofibrate groups were well matched for baseline characteristics (4) (Table 1).
Internal validity was strong; participants were individually randomised and groups were well matched for baseline characteristics.
Results The two groups were well matched for baseline characteristics, and withdrawal rates were similar in both groups (5%).
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