Sentence examples for matches annotation from inspiring English sources
A transcriptional start site motif was also related to the under-expressed contextual gene sets, which matches annotation for the androgen receptor AR.
From the MSigDB analysis, one of the significant annotations related to the over-expressed contextual gene set is a transcriptional start site motif that matches annotation for a member of ETS oncogene family, ELK1, which is involved in pro-apoptotic and pro-differentiation in neuronal cells [ 29], and MAPK- ELK1 signaling pathway that contributes to cell survival [ 30].
For the MSigDB annotations of the under-expressed contextual gene set, the presence of a transcriptional start site motif was statistically significant, which matches annotations for vitamin D receptor VDR.
The error categories for the false positives were: partial match; annotation error; out of corpus scope (e.g. larger drug molecules such as protein drugs); not a chemical (e.g. the term "metabolite").
We observe that 89% of exonic variants from VEP get an exactly matching annotation from ANNOVAR and 96% of exonic variants according to ANNOVAR get an exactly matching annotation from VEP.
The higher the percentage of matched annotation terms, the higher the agreement between trait-pairing predictions and prior knowledge.
However, the matching annotation rate is 44% for LoF variants, the set of variants of most interest for biological and medical studies.
The final column shows the 'Overall match rate', which is the percentage of the variants with a given annotation when using either REFSEQ or ENSEMBL ('REF+ENS') that have a matching annotation when using the two transcript sets.
Column nine shows the overall exact match rate, which is the percentage of variants with an annotation from either ANNOVAR or VEP ('ANV+VEP') that have an exactly matching annotation from the two tools.
The list of each unisequence identified and its best BLASTX match annotation is provided in Additional file 1. Records of analysis for these collections can be accessed at the FIESTA database developed at the Plant Biotechnology Institute, National Research Council Canada [ 16].
