Your English writing platform
Discover LudwigSuggestions(5)
Exact(11)
Genotypes were compared between normal adjacent tissue and matched tumor samples; informative loci were those that were heterozygous in the normal tissue.
Second, we evaluated whether the status of biomarkers such as HER2 in captured CTCs faithfully reflects biomarker status in matched tumor samples.
Finally, we find that the status of biomarkers such as HER2 in captured CTC generally reflects biomarker status in matched tumor samples.
This is further supported by the positive correlation between RAD21 gene expression and protein expression, as assessed by immunohistochemistry in matched tumor samples.
Serum samples were available for a subset of 6 controls and 31 patients with ovarian cancer that had matched tumor samples in the TARS IHC analysis.
However, with respect to the RQ values in the matched tumor samples at least, the group was considered representative for the remaining 87.5% of single tumor samples.
Similar(49)
The adjacent normal sample assigned to the tumor cluster was most closely related to its matched tumor sample (matched pair 2).
To investigate methylation status in normal tissue, a matched tumor sample was equally processed and immunoblotted with anti-R methyl antibody.
In some instances, we observed samples with ~50% in the normal tissues but either hyper- or hypo-methylation in the matched tumor sample (Fig. 4; Table S2).
Larger nested case control studies within cohorts—using both pre-diagnostic and post-diagnostic serological samples in combination with matched tumor sample to discern potential effects on antibody levels by tumor tissue or treatment effects could provide valuable information.
To allow more direct comparisons to the HER2 IHC scores obtained from matched tumors samples, we developed a scoring system to quantitate HER2 expression using a 0 3+ score in CTCs (Figure 5C) and then computed an H-score to provide a weighted score based on the number of CTCs with a given level of expression.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com