Sensitivities of 2D, 3D, and S analysis were compared using McNemar's test for matched proportions extended to clustered data to account for within-patient correlation [ 7].
20 We need to recruit 256 residents to identify a significant difference in PIP identification rate (this sample size was calculated based on the McNemar χ calculation for matched proportions).
Tables 1 and 2 and Figure 1 show the comparison of clinical and histological data, response to therapy and prognosis among ANCA-positive IgAN, ANCA-negative IgAN and AASV patients with matched proportions of crescentic glomeruli.
With matched proportions of glomeruli with crescents, ANCA-positive IgAN patients showed worse renal function at renal biopsy, but tended to have a better response to aggressive immunosuppressive therapy in the short-term and a greater possibility of withdrawal from dialysis, when compared with ANCA-negative patients, and were similar to patients with AASV.
Regarding the matched proportions of crescentic glomeruli, ANCA-positive IgAN patients showed a trend of lower eGFR compared with ANCA-negative IgAN patients, but were consistent with AASV patients at baseline [21.2 (10.9, 47.7) mL/min/1.73 m versus 47.0 (87.1 87.1) mL/min/1.73 m versus 19.5 (9.2, 52.4) mL/min/1.73 m, P = 0.12].
Forty ANCA-negative patients with IgAN and 40 AASV patients were selected by stratified random sampling as two control groups, with matching proportions of crescentic glomeruli.
The relative proportion of each category approximately matched the proportion present on the microarray, suggesting that differential expression and additivity occur at equal rates for all functional types of genes.
The onset, time-dependent accumulation, and size-dependent profile of caspase-3 activity matched the proportion of cells undergoing morphological transformation on the nanodot arrays.
Birth certificate matches were made for 916 cases, resulting in a match proportion of 83%.
A final algorithm that used multiple combinations of identifying variables resulted in a match proportion of 87%.
