Sentence examples for matched primary specimens from inspiring English sources

Mirroring other cell-adhesion molecules, TM expression tends to be lower in metastatic lesions than in matched primary specimens (Tezuka et al, 1995; Hamatake et al, 1996; Tabata et al, 1997; Ogawa et al, 2000).

To pave the way for predictive biomarker development, we assessed differences in expression of targets of currently approved drugs in matched primary and metastatic specimens from 34 patients.

Many metastatic RCC patients have either primary or metastatic tumor tissue (but not both) available for analysis, and our purpose was therefore to determine differences in expression of these drug targets in matched primary and metastatic specimens.

To establish bcDMPs associated genes as novel epigenetic biomarkers for breast cancer, we aimed to validate differentially methylated CpG sites in an independent set of MZ twins discordant for breast cancer, as well as in matched primary breast cancer specimens.

In summary, we have investigated S100A4 expression at the molecular and cellular level in matched primary and metastatic PTC specimens.

The clinical relevance of these findings was confirmed in matched primary and metastatic human HNSCC specimens, which exhibited increased levels of ADAM17 expression and concomitant CD44 cleavage compared to controls.

In the present study, we have shown increased S100A4 expression in thyroid tumour cells metastasised to regional lymph nodes or distant organs and at the tumour invasion front in matched primary thyroid tumour and their metastatic specimens.

Increased β1-integrin was detected in metastasis (MT) breast carcinoma specimens compared with their matched primary tumors (PTs).

In our study, we surveyed a set of matched primary and metastatic tumors, for the expression of E-cadherin in the HCC specimens.

Early local recurrence specimens demonstrated a significantly increased infiltration of CD11b+ myeloid cells (P=0.0097) but decreased CD31-positive vessel density (P=0.0004) compared with their matched primary samples.

Studies on matched primary tumors and their metastastic lymph nodes from the same patients are rare and severely limited in the number of samples because of the difficulties of obtaining suitable specimens.