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Furthermore, analysis of only the subgroup of tumor material that had matched normal counterparts yielded also a significantly lower Tensin2 and -3 expression in the tumor tissues (n = 48; p<0.001).
Similarly, TN paired set separated the tumor samples from their matched normal counterparts.
The current study also showed for the first time significant up-regulation of CDCA3 in OSCC-derived cell lines and primary OSCCs compared with the matched normal counterparts.
Eleven formalin-fixed, paraffin-embedded (FFPE) prostate adenocarcinoma tissue samples with Gleason between 5 and 10 and their matched normal counterparts were provided by the Pathology Unit of San Salvatore Hospital of L'Aquila.
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Second, each tumour model has its matched normal counterpart as a comparison.
In the present study, there was also a trend towards elevated serum somatostatin levels in the <45 yr old SLE patient group or 45 – 55 yr old group compared to their age-matched normal counterparts (Table 1).
Previous gene expression profile analyses comparing CAFs and fibroblasts derived from matched normal adjacent breast tissues have demonstrated significant differences between the CAF and their normal counterparts but, to the best of our knowledge, no prior studies have addressed whether CAFs derived from various breast cancer subtypes harbor subtype specific gene expression signatures.
All the cases had matched normal tissues.
To investigate Mitostatin expression in prostate cancers, we evaluated by qRT-PCR analysis 10 matched normal-cancer samples and by immunohistochemistry (IHC) three tissue microarrays composed of 293 specimens including 124 prostate cancers and 43 normal counterparts.
Significantly, both Tensin2 and Tensin3 expression were lower in a single RCC patient's kidney tumor extract as compare to its adjacent normal counterpart (matched).
Next, we investigated dyskerin expression in 24 prostate tissue samples on a tissue microarray with 12 matched tissue cores of prostate cancer and the respective normal counterparts.
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