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We use data on first-generation immigrants and their native matched individuals from the 1975 and 1980 Censuses.
We constructed a dataset of matched individuals from the Agincourt HDSS and the AHC by linking individuals' fingerprints in dataset2 with the fingerprints in dataset3.
To identify differential methylation associated with the highest concentrations of BPA in this cohort, the analysis described above was repeated using a more stringent cutoff for the BPA-high group (n = 5, where urinary BPA concentrations are greater than 2.60 ng/mL, the median concentration of age and gender matched individuals from NHANES 2009 2010) (Additional file 1: Table S1).
Matched individuals from the A&E Department cohort could be found for 547 of the 565 individuals in the mobile fall prevention cohort.
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Furthermore, our ability to match individuals from the Brecon cohort to healthy population controls has enabled us to adjust effectively for important confounding factors.
Record linkage was performed using an upgraded version of an ad hoc software application that was previously designed and validated in Italy and Switzerland (Geneva) to match individuals from AIDS and cancer registries while protecting patient anonymity (Dal Maso et al, 2001; Clifford et al, 2005).
These costs are obtained by comparing the annual resources available to dropouts to the resources available to matched individuals, who differ from dropouts only because of their education and of unobservables.
Due to the matched nature of this sample, if one of the participants was missing data on a particular scale (e.g., depression), all matched individuals were removed from that analysis.
The patients were compared to a population norms (Sweden) from age and gender matched individuals (n = 1180) obtained from the Swedish SF-36 database for population norms (n = 8930) [ 8].
Finally, a comparison of presurgical and postsurgical plasma samples from matched individuals did not show any significant differences.
Although circulating microRNA levels in plasma and serum from matched individuals were shown to be generally highly correlated in healthy individuals (Mitchell et al, 2008; Wang et al, 2012), it is unknown if this correlation also applies to patients with tumours or diseases.
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