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A similar study, using isolates obtained from participants of the Amsterdam Cohort Study and samples matched for time since seroconversion, found an increase in replicative fitness over time [15].
However, Gali et al. [14] used the same fitness assay approach in a study comparing Amsterdam Cohort Studies samples from the mid-1980s againsamplesles from the late 1990s, matched for time since seroconversion, coreceptor usage, and viral subtype.
One study suggested a lower replicative fitness in HIV-1 isolates obtained from patients infected in 2002 2003 compared to isolates from patients infected between 1986–1999 [14], but samples were not matched for time since seroconversion.
However, we compared attendance data matched for time of year to minimize bias (eg, related to holidays).
Two controls (SLE patients without major infections), matched for time of follow-up until the event and age at diagnosis, were selected for each case.
Down syndrome and euploid case samples were matched for time in storage to take under consideration an eventual loss of fetal DNA in maternal plasma as a function of time in freezer storage.
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Ruiz-Irastorza and colleagues found that, of the 83 patients with a major infection, 22% were taking an anti-malarial compared to 77% of patients matched for time-to-event and age at diagnosis with no major infection history [ 1].
We used risk set sampling (by matching for time at risk) but did not allow case-patients to be eligible to be controls before to becoming cases.
Groups were matched for age, time period since delivery, smoking status and alcohol consumption.
That is why we conducted a case control study matched for diagnosis, time of follow-up, BMI, gender, age and type of prosthesis.
They found that despite being matched for total time and relative intensity, the energy cost of continuous aerobic exercise was greater than that of intermittent resistance exercise (34).
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