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When the control group was matched for stage and PS, no survival difference was seen (P=0.91).
Each of the younger breast cancer patients (n = 276) was matched for stage and grade to two older control patients (n = 552).
However, no survival difference was observed between the same cases and the control group matched for stage and PS (P=0.91; Figure 2B).
For each HIV-positive case patient, three HIV-negative controls were identified who were matched for stage, histology, age (within 5 years of the case patient) and date of diagnosis (within 5 years of the case patient).
Two had a significantly older HIV-negative cohort (Hoffman et al, 2000; Tirelli et al, 2000), while the other was not matched for stage of disease (Vyzula and Remick, 1996).
Analysis of large numbers of cases matched for stage and therapy will allow definitive clarification of the value of p53 mutational status in prognostication, and possibly choice of therapy.
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In a previous study, Sorensen et al did not match for stage, but did have staging data.
Briana Williams, a molecular biologist at the Louisiana State University Health Sciences Center in Shreveport, and her colleagues decided to look for biological differences in 100 prostate tumors, matched for disease stage and other clinical factors.
Tumours were again matched for grade, stage and presenting PSA.
In total, 62 patients who failed radiotherapy were matched for T stage, laryngeal subsite and smoking history to a group of 62 patients successfully cured by radiotherapy.
Since in this study the groups were matched for NSCLC stage and the treatment protocols used were the same in both the groups, the results support the hypothesis that NSCLC is not more aggressive in the immunocompromised.
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