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A blind record evaluation on suicide victims and matched controls has been performed, including non-fatal suicidal acts.
The difficulty of obtaining adequate numbers of disease-free and age and sex matched controls has been a problem in previous investigations, especially in an elderly population.
Comparing the extended-adaptation Drosophila with their matched controls has allowed useful physiological and genetic analysis of the mechanistic basis of extending adaptation [ 27].
Gene expression profiling of biofluids and tissues from SAID patients and matched controls has provided a wealth of information into possible mechanisms of disease development, chronicity, and therapeutic response.
This method of using matched controls has previously been used in a number of studies to successfully determine familial recurrence risk in different disorders, including obsessive compulsive disorder (Mataix-Cols et al., 2013), autism (Sullivan et al., 2012) and criminal conduct (Frisell et al., 2011), but so far has not be applied to multiple sclerosis.
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The psoriasis cases were diagnosed by dermatologists and their matched controls had no history of psoriasis, no family history of psoriasis or other auto-immune disorders.
All matched controls had exactly the same experimental setup (choice of distractors objects during learning and testing as well as presentation order) as their respective CP participants.
However, several studies that have directly assessed subjective pleasure responses in patient populations of individuals with MDD and matched controls have not found evidence to suggest that depression is associated with diminished hedonic capacity ([25], [26]).
Similar proportions of case-patients and matched controls had received Lyme vaccine.
As intended, the AD spouses and their matched controls had no significant differences in demographics.
In comparison, only 74 (28%) of random controls and 69 (26%) of age matched controls had chest radiography, and 45 (17%) of random controls and 44 (17%) of age matched controls had basic laboratory investigations (P<0.001 for all comparisons).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com