The search uncovered a total of 15 articles, including 5 level I randomized controlled trials, 6 level III retrospective matched controlled trials, and 4 level V case reports.
Design: Prospective matched controlled trial.
Our study used a historically matched controlled trial design, controlling for age, sex and disease type, to examine the impact of the NC programme on patient outcomes, and demonstrated that the NC cohort had favourable patient health and service outcomes in comparison with the non-NC cohort.
This matched controlled trial, the LEAP intervention study, was uniquely tailored to compare the intervention and control schools at baseline (March/April, 2010), post-testing (after 7-weeks; April-June, 2010) and at a follow-up (after 8-months; November, 2010).
Measurable patient benefits from case-matched control trials [ 37– 39] include less pain, less blood transfusions, fewer wound infections and pulmonary complications, and faster recovery as well as a better cosmetic result.
If 750 DAA-treated patients were enrolled and approximately 1,500 matched control patients identified, this trial would have adequate power when testing two hypotheses, IRP A and IRP B, corrected for multiplicity testing.
Prospective non-randomized trial with matched control group.
25 26 27 28 29 To evaluate this programme, we designed a randomised controlled trial comparing ParkFit with a matched control intervention.
In contrast, subjects were equally likely to tolerate approaches by the dominant signaller following postgroom trials and during matched control periods.
This evidence is supported by several 1-year, open-label trials that included matched control groups (Nobili et al. 2002; Rodriguez et al. 2002; Hashimoto et al. 2005; Table 10).
