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The study design was aimed to identify and catalog genome-wide copy number alterations and differential gene expression in different types of North-Indian posterior posterior fossa tumors and matched control tissue through Molecular Inversion Probe (MIP) Based and Human Transcriptome Array.
We detected somatic mutations in NAF that were not present in the matched control tissue.
In addition, we compared the performance between our pipeline and the pooled-sample model of GATK when the matched control tissue was unavailable.
Recently, Beuschlein et al performed exome sequencing of tumor and matched control tissue samples from nine males affected with hypokalemic PA and bearing wild-type Kir3.4.
Postzygotic single-nucleotide mutations had not been previously studied at genome scale in clinically unremarkable individuals, largely due to technical challenges caused by sequencing errors and the lack of matched control tissue.
The low-active splice form of the PKM-type pyruvate kinase (PKM2) is present at higher concentration in cancers compared to matched control tissue (Bluemlein et al., 2011; Christofk et al., 2008).
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Furthermore, CSNK2A1P mRNA was overexpressed in lung tumor tissue from seven out of 29 (∼25%) tumor samples as compared to matched control tissues (Fig. 1B).
The recruitment of CD-3 positive T-cells into the fetal gut paralleled that of PMN: in preterm lambs exposed to endotoxin for 2d, no significant increase of CD-3 expressing T-cells in the lamina propria was observed when compared with time matched control tissues of 125d GA (data not shown).
In cases where matched control tissues are available, utilizing data from the matched controls may increase detection accuracy for pSNMs.
Paired samples t-test was used for comparison of adipocytokines levels in tumor and matched control tissues.
Methylation levels at IGF2 DMR0 were examined in 22 breast tumours and matched control tissues from the same patients.
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