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Exact(5)
Creating a baseline from multiple samples is essential for population and family studies where a matched control is not available.
Therefore, even when a matched control is available, a secondary analysis using multiple unmatched normal samples as the control can be performed (in additional to a paired analysis) to improve the detection of true positives.
A modification of the allele ratio in the carcinoma relative to the matched control is referred to as AI, and the presence of an additional peak is referred to as MSI.
If no matched control is found for a particular case (A or C) with a date of birth within 1 month either side of the case's date of birth, the range will be expanded to 3 months either side (or 6 months either side if the case's age at index diagnosis of primary breast cancer is under 50 or over 70).
If no matched control is found for a particular case with a date of birth within 1 month either side of the case's date of birth, the range will be expanded to 3 months either side (or 6 months either side if the case's age at index diagnosis of primary CRC is over 75).
Similar(55)
The matched control was, therefore, also removed from further analysis.
In addition, a matched control was unavailable for 21 patients.
22 One matched control was selected for each intervention patient.
One patient withdrew for personal reasons; subsequently, the matched control was excluded from analysis.
Only patients with at least one matched control were accepted for the final study set.
More well-designed prospective studies, especially with propensity matched control, are needed to solve these limitations.
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