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Potential controls were identified after the matched case had been enrolled in the MalariaGEN study.
For them, one new control, born in the same year, was randomly picked from the 388 leftover controls (i.e. controls whose matched case had not used services at least three times).
Of the 220 cases and 570 controls included in our previous study on Oncotype DX, there were 13 cases or controls with insufficient tumor for this study; an additional two controls became uninformative because their matched case had no tumor tissue.
Up to twenty controls for each case patient were selected randomly from the cohort to be matched for territorial unit of recruitment, gender, age at cohort entry, date of entry into the cohort and were at risk for the outcome at the time when the matched case had the event.
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36.5% of the matched cases had no detectable level of flotillin 1.
Subjects who were not included in the breast cancer risk analysis consisted of 108 cases with carcinomas in situ and 206 matched controls, and 123 cases (whose matched controls had genotyping failure) and 125 controls (whose matched cases had genotyping failure).
The controls had no dementia diagnosis for the entire time period 2000 08, had to have registration at the practice for at least 3 years prior to the year of diagnosis of their matched case and had a recorded consultation in the year of diagnosis of the matched case.
We intend to identify all nsSNVs from representative samples from all data sets that have matched case and controls and also have exome and RNA-Seq data.
As with cases, all controls had to be current users of one of the study contraceptives, to have at least six months of enrolment in their health plan before the index date (the event date of their matched case), and to have used a study contraceptive after 2002.
A recently matched case control design has been applied in cross sectional data to investigate the relationship between youth assets and sexual intercourse among 13 14 year olds [ 29].
However, in our analysis we excluded 208 fathers (104 pairs) because either their job information was missing or their matched case or control counterparts had missing job information.
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