Sentence examples for matched annotation from inspiring English sources
The higher the percentage of matched annotation terms, the higher the agreement between trait-pairing predictions and prior knowledge.
For example the term 'xenobio' matched annotations for cytochrome P450's and UDP-glucuronosyltransferases, which are known components of Phase I and Phase II metabolism for xenobiotic compounds in blue crabs [ 28], but 'xenobio' also matched annotations for cyclin-dependent kinase 9, which has a more general role in cell cycle regulation.
We observe that 89% of exonic variants from VEP get an exactly matching annotation from ANNOVAR and 96% of exonic variants according to ANNOVAR get an exactly matching annotation from VEP.
A transcriptional start site motif was also related to the under-expressed contextual gene sets, which matches annotation for the androgen receptor AR.
However, the matching annotation rate is 44% for LoF variants, the set of variants of most interest for biological and medical studies.
Column nine shows the overall exact match rate, which is the percentage of variants with an annotation from either ANNOVAR or VEP ('ANV+VEP') that have an exactly matching annotation from the two tools.
A full comparison of the matching annotation results (CDSs) obtained from the genome assemblers and annotation pipelines used is presented in Figure 1a; CDSs were compared on the basis of sequence match at 100% similarity – to compare CDSs with exact start and stop matches.
From the MSigDB analysis, one of the significant annotations related to the over-expressed contextual gene set is a transcriptional start site motif that matches annotation for a member of ETS oncogene family, ELK1, which is involved in pro-apoptotic and pro-differentiation in neuronal cells [ 29], and MAPK- ELK1 signaling pathway that contributes to cell survival [ 30].
Monoisotopic match scores: The absolute score counts an isotopic matched pair annotation wrong even if it misses one peak or includes one extraneous peak (for example a noise peak).
When results didn't match, annotations were corrected following cDNA database information.
