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A referent cohort sample for the NECS subjects was constructed utilizing genotype data from the Illumina iControlDB database and principal components analysis was used to match cases and controls by genetic background.
No attempt to match cases and controls was made.
We tried to match cases and controls (nine cases and 18 controls).
To control for selection bias, frequency matching techniques were used to match cases and controls on gender and race dimensions.
Ethnicity has been the most common way to match cases and controls based on self-reported ancestry.
Another limitation of the present study involves the failure to accurately match cases and controls on age and sex.
Similar(40)
The propensity score method was used to match case and control cohorts.
Because this study is a match case and control study, association between case/control status and LOM was examined using conditional logistic regression (fixed effect).
Day of week was modeled using six dichotomous variables and was necessary because we did not have enough data to match case and controls by day.
The included studies also generally showed an effort to age-match cases and controls.
Matching by use of specific variables may not completely help eradicate bias as there may be other confounding factors not matched for and it is also possible to "over-match" cases and controls.
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