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Nathan and Mimsy, in particular, are strongly influenced by Rocky and Mugsy, with Nathan taking on the role of the diminutive mastermind (like Rocky) who is constantly thwarted by his large but dim-witted accomplice (like Mugsy).
There's something sly and fun about him that's perfect for a trickster mastermind like Verbal.
Most remarkably he can, without compromising this integrity, happily follow the occasional diet mastermind like Dr. Fuhrman.
The character of Rudolph Hayes was crafted to be an ambiguous character: either he was a genius who was adept at solving crime, comparable to Sherlock Holmes, or he was a criminal mastermind, like Professor Moriarty.
They made their project work without a singular creative mastermind like Judge, who wanted nothing to do with the spin-off and was on his way out the door to bigger (and much more lucrative projects) with Fox anyway.
As pretty boy deCourcy, Xavier Samuel is pitch perfect as the Stillman-esque male, holding the winning hand yet a little clueless, and certainly no match for a mastermind like Lady Susan, who in another life could have been a Disraeli or Metternich.
Similar(54)
CSL then recruits the co-activator mastermind-like (MAML) for transcription of Hey/Hes to inhibit Runx2.
Notch ICD subsequently translocates to the nucleus and forms a ternary transcriptional activation complex with CSL (also known as RBP-Jk) and Mastermind-like (MAML) to induce expression of downstream target genes, including Notch-regulated ankyrin repeat-containing protein (NRARP), Hes, or Hey genes [1, 2].
Mesp2 suppressed itself through a feedback loop and suppressed Notch activity by destabilizing Mastermind-like 1 (MamL1), one of the core components of the nuclear NICD complex, at the post-transcriptional level via pathways other than the proteasome pathway (Sasaki et al., 2011).
Measurements were taken both in the absence and in the presence of Mastermind-like-1 (MAML1).
This depends on binding of ICN to the transcription factor CSL [7], [17], [18] and recruitment of Mastermind-like coactivators [19] [22].
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