GLP-1 functions together with the LAG-1 CSL and SEL-8/LAG-3 mastranscriptioncription factors (Christensen et al. 1996; Tax et al. 1997; Doyle et al. 2000; Petcherski and Kimble 2000) and regulates transcription of genes needed for the maintenance of germline stem cells, including sygl-1 and lst-1, whose mechanisms of action are unknown (Kershner et al. 2014).
Renewal of stem cells and ongoing active terminal differentiation require the progressive fine tuning of transcriptional programs, which are masterminded by Transcription Factors (TFs).
To be certain that dSno does not play any role in Notch signaling in wing development we conducted coexpression experiments with dominant negative forms of both Notch (UAS.DN-Notch) and the Notch pathway transcription factor Mastermind (UAS.MamN).
Cowell, the mastermind behind The X Factor, is the most Roman Emperor-like motherfucker currently known to the UK.
NICD translocates to the nucleus and forms a transcriptional complex with C-promoter binding factor 1 (CBF1), Mastermind (MAML) and transcriptional co-activators thereby converting CBF1 from a transcriptional repressor into an activator.
Choi et al. used HDX MS to study the Notch transcription complex formed between the Notch intracellular domain (NCID), the DNA-binding factor CSL, and Mastermind Family 1 protein (MAML1).
The former, a paralog of the pair-rule gene engrailed, is a transcription factor that is expressed in neuroectodermic cells [13], while mastermind is a key component of the Notch signaling pathway, which determines cell fate and regulates pattern formation.
Although One Direction ultimately fell short of winning on The X Factor, the show's mastermind, Simon Cowell, offered the act a recording contract soon after the season ended.
Among them: visionary, expert, futurist, mastermind, go-getter, change agent.
Cowell, the mastermind behind global TV franchises "The X Factor" and "Got Talent", unveiled plans on Monday for the first global audition channel, called The You Generation, that will be launched in 26 countries on March 20.
