I want to learn, to relax, to release stress, and to master the sequences.
At the end of the activity, students are expected to have mastered the sequence of the integrated PE, and to complete it in ten minutes.
The special chair-making tools we used back then have been mothballed, and none of my current production guys are masters of the sequence of processes required to build these pieces.
Finally, the loss of the master sequence obviously implies the loss of the information contained in it.
Along the line of descent (in yellow), as well as in the other lineages (in red), the presence of the master sequence is intermittent, and the ancestor of the lineage becomes a close mutant.
Starting from the master sequence, the average mutational neighborhood of these units of replication, at progressively higher Hamming Distances, is plotted in figure 6 (core neutral mutants).
As a result, at high mutation rates these sequences compete with the master sequence (the single sequence that has higher fitness than all other sequences), and can win this competition at sufficiently high mutation rate by sheer abundance.
Altogether, there seems to be a correlation between the distributions of mutants of the master sequence and the distribution of functional classes present in the field.
Altogether, we conclude that stallers are an intrinsic problem for the system, and that the master sequence of the full model has evolved some "mutational control" over them.
The important difference between the master sequence and the other units of replication (at high Hamming Distance) is that the latter has more stallers in the mutational neighborhood than the former, that is, the probability that a staller is produced (λ S ) is higher.
