That is, the profiles for large values of f C become widely distributed, with a master sequence that seems under-represented.
This is particularly clear for σ = 0.2 and σ = 0.15 with a master sequence that represents around 50 and 40% of the population, respectively.
Conversely, a master sequence that, having once been displaced, was never observed to come back to high frequency in the population.
The fraction of all the Hamming Distance (HD) = 1 mutants of the master sequence that fold into units of replication is λ ms = 0.06 (note that a broad definition of neutrality is adopted, as folding into a unit of replication suffices, and replication rate is not taken into account).
Independent HCV isolates of a given subtype typically differ by 6%to10%0%, and genetic variation between viral genomes within an individual is usually 1%to3%3% because of the replication of HCV as a quasispecies (that is, a collection of genetic variants that clusters around a master sequence and that evolves as a unit [ 4]).
Only the sequences that identified the correct family as verified by the master list accession numbers were chosen as family members.
The network approach enabled the identification of putative "master" sequences and provided evidence that within a genus these master sequences are associated with distinct U3 regions.
At the time, Jennifer Trosper, the chief mission manager, said the Spirit continued to use a day-old master sequence of commands that kept it communicating but not using the instruments on its robotic arm.
However, the new master sequence evolves so that what is classified as junk behaves partially as stallers.
Here we analyze the distribution of such classes in the mutational neighborhood of the master sequence, to conclude that the evolved quasispecies is selected for the peculiar distribution of its mutants.
