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Interestingly, the master sequence seems to belong to a "steep" (as opposed to "flat") quasispecies.
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That is, the profiles for large values of f C become widely distributed, with a master sequence that seems under-represented.
The sequence seems invented on the spot.
Philip Reeve's Mortal Engines sequence seems a natural for it.
The aforementioned launch sequence seems a little lame now, too.
The master sequence does not seem to differ much from random sequences for what regards junk, stallers, and hybrids.
Even in the early stages, the sequence seemed gargantuan.
Stallers, junk, and hybrid sequences in the neighborhood of the master sequence seem not to be significantly different from random.
Altogether, there seems to be a correlation between the distributions of mutants of the master sequence and the distribution of functional classes present in the field.
The sequencing revealed only one master sequence with a few point mutations (Supplementary Figure S1C).
First, the master sequence, i.e. the sequence with the highest replicative ability, is lost [ 1].
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