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The extent of the mutational control the master sequence reaches is surprisingly deep (Hamming Distance ≈ 10, where it becomes indistinguishable from random).
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We observe that the population distribution requires very long transients both to A) reach equilibrium and B) to show a clear dominating master sequence.
The sequencing revealed only one master sequence with a few point mutations (Supplementary Figure S1C).
First, the master sequence, i.e. the sequence with the highest replicative ability, is lost [ 1].
C i) → Nucleotide at position i in the consensus or master sequence.
In particular, they propose a novel definition of the chromosomal master sequence.
In practice, such strategy favors the master sequence while hindering everybody else in the long run.
The probability that two catalytic strands of the master sequence form a complex is 0.90.
The phenotype associated with the master sequence is catalytic and has two dangling ends.
Interestingly, the master sequence seems to belong to a "steep" (as opposed to "flat") quasispecies.
On the one hand, there is a master phenotype which, as it is made up of a single genotype, the master sequence, has null mutational robustness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com