Sentence examples for master sequence in from inspiring English sources

These analyses identified the HSVd sequence variant already reported in databases with the accession number X06873 [48] as the most abundant (master sequence) in the infecting viroid population (Fig. S1).

Helpers make up to about 50% of the mutational neighborhood of the master sequence, in contrast to the case of random sequences (≈ 10%% ) and those optimized for replication.

However, the usual mathematical criterion for defining the error threshold is the loss of master sequence in the absence of back mutation.

The focus in the present study is on cases which exhibit only a single compotype each (NC = 1), whereby compositional entities are disposed around a single center of mass, analogous to the master sequence in sequence-based quasispecies.

As the number of sequences is an intrinsic property of the classification, and depends on the Hamming distance with respect to the master sequence, in order to change the robustness of each Hamming class, we assume that the quality factor per digit of each species, qi, depends on its sequence, as previously done in [ 48].

> -wrap-foot> The units of replication belonging to the steep quasispecies not always display a unique master sequence: In some cases (4., 5., and 6. in table 1), a small group of core neutral mutants with almost identical mutational neighborhood substitutes it.

Given these caveats regarding distribution of fitness for chromosomal master sequences in the presence of aneuploidy and regarding sub-population interactions, we reach the conclusion that quasispecies theory is indeed applicable to cancer and stem cells, but only in the context of aneuploid chromosomal master sequences, neglecting the underlying nucleotide errors.

Variations in the quasispecies master sequence (defined in practical terms as the consensus HCV sequence within a patient) between individuals have also been associated with outcome of therapy.

Units of replication arise as mutants of the evolved master sequence, and, in turn, make more mutants.

Considering the Tnt1 superfamily of retrotransposons in the genera Solanum, Lycopersicon and Nicotiana as a population of sequences with a common ancestor, a Network study was carried out with the aim of testing the hypothesis that a common α master sequence exists in Tnt1-superfamily.

This explains why units of replication closer to the master sequence are selected (in the short run), as seen in the field (fig. 8), why the peak of the distribution of helpers is one step after (in Hamming Distance) from that of units of replication, and why the peak of the distribution of stallers is at higher Hamming Distances.