Sentence examples for master sequence has from inspiring English sources

On the one hand, there is a master phenotype which, as it is made up of a single genotype, the master sequence, has null mutational robustness.

The master sequence has a limited fraction of them in its mutational neighborhood, which exposes it to the risk of invasion by parasites.

In the case where stallers are removed from the field, the new catalytic lineage lacks a persisting master sequence, has high neutrality (≈ 0.3 ) and few helpers in the mutational neighborhood.

Conversely, a master sequence that, having once been displaced, was never observed to come back to high frequency in the population.

The phenotype associated with the master sequence is catalytic and has two dangling ends.

As a result, at high mutation rates these sequences compete with the master sequence (the single sequence that has higher fitness than all other sequences), and can win this competition at sufficiently high mutation rate by sheer abundance.

Altogether, we conclude that stallers are an intrinsic problem for the system, and that the master sequence of the full model has evolved some "mutational control" over them.

In both cases, the quasispecies have no persisting master sequence, and the sequence variability in the field is high.

However, the cases that resist to the highest mutation rates do have a unique master sequence (1., 2., and 3. in table 1).

Aneuploid events can cause large phenotypical variations, even a single error leading to chromosomal loss or addition can have large effects, therefore the fitness distribution around a master sequence is expected to display a sharp decay from the master sequence peak, in line with the types of fitness distribution known to express the error threshold.

Variations in the quasispecies master sequence (defined in practical terms as the consensus HCV sequence within a patient) between individuals have also been associated with outcome of therapy.