Sentence examples for master regulators in from inspiring English sources

Seiji Tsuge of Kyoto Prefectural University explained the role of HrpG and HrpX (master regulators) in the regulation of Xoo hrp genes (which encode the T3SS and its secreted proteins).

Importantly, expression of lineage-defining master regulators in STAT-deficient cells fails to fully recover the chromatin signature of STAT-dependent enhancers.

These proteins are also master regulators in the Hippo-protein-mediated signalling pathway, which controls organ size and has a tumour-suppressor function6.

Janky R, Binda MM, Allemeersch J, Van den Broeck A, Govaere O, Swinnen JV, et al. Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma.

HNF1α (Hepatocyte Nuclear Factor 1α) is one of the master regulators in pancreatic beta-cell development and function, and the mutations in Hnf1α are the most common monogenic causes of diabetes mellitus.

In a series of stunning papers published over the past few years, Califano and several members of his lab have identified dozens of proteins that they say act as "master regulators" in cancer cells, seamlessly orchestrating the activities of hundreds of other proteins, which, in turn, force the cells to divide and persist in a malignant state.

In mice, foxi1 has been reported to function as a master regulator in regulating differentiation of FORE cells in the inner ear [3] and intercalated cells in the urinary system [25].

This work is the first large-scale study attempting to identify the genetic networks regulated by RUNX1, a master regulator in the development of the hematopoietic system and leukemia.

As hypothesized, c-Myc is the master regulator in the USP2a-driven γ-GCS regulation, as c-Myc silencing reverts the expression and activity stimulation elicited by USP2aWT (Supplementary Figures 6a d).

Although we could not discern a single functional class of genes trans-regulated by Rgs7, our data suggests that Rgs7 is a master regulator in this region controlling other genes encoded in Qrr1 in trans (Table S1).

Given that NFκB is a master regulator in the immune system [ 23, 71, 77], RhoGTPases may, through NFκB, regulate many aspects of immunity, in particular innate immunity.