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Recent studies of tomato HSFA1a mutants and an Arabidopsis HSFA1a/1b/1d/1e quadruple mutant revealed that members of HSFA1 genes can function as master regulators for the HSR and play important roles in cross-regulation for abiotic stress responses (Mishra et al. 2002; Liu et al. 2011).
Androgen receptors are not the master regulators for male behaviours, but rather, the researchers say, a "gain control mechanism" which amplifies such behaviours or, when the receptors are absent, dials laddish behaviour down.
Nevertheless, significant progress has been made in the identification of signaling pathways and master regulators for drought tolerance.
These results strongly suggest that VtrA and VtrB are master regulators for virulence gene expression in the Vp-PAI and play critical roles in the pathogenicity of this bacterium.
Rab small GTPases are considered as the master regulators for membrane trafficking.
This is not surprising because they are master regulators for early and middle meiotic genes.
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Among intracellular metabolites, α-keto acid such as αKG turns to be a master regulator for catabolite regulation and co-ordination of different regulations [139].
Scleraxis may thus be a master regulator for tenocytes, and regulation of fibrillar collagen synthesis may represent one aspect of this role.
This was confirmed at the genomic level by strong up-regulation of Hif1a, which acts as the master regulator for the expression of genes involved in the hypoxia response in most mammalian cells [ 42, 43].
This miRNA would appear to be a master regulator for several aspects of immunity, including the regulation of cytokines, such as tumor necrosis factor-alpha (TNF-α), functioning in the negative feedback control of innate immunity in Toll-like receptor (TLR) signaling, and is involved with T-cell activation and is highly expressed in mature human memory T cells [ 41].
Like Th1 cells, T-bet is the master regulator for ILC1 cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com