Sentence examples for master regulators and from inspiring English sources

Many other TFs are further downstream of the NAC and MYB domain master regulators, and form the hierarchical and non-hierarchical regulation networks.

Elucidating the mechanisms underlying the effects of DNA copy number aberrations on expression regulation in cancer would aid in identifying master regulators and the design of therapeutic modalities that specifically block key elements in a regulatory network.

Different master regulators and associated network for proteins expressed in tumours only (To) or significantly regulated when compared to healthy liver of non-transgenic control animals (T + UR + DR).

Multitherapy resistance was associated with a semi-stable cell state that was characterized by an altered DNA methylation pattern at promoter regions of mesenchymal master regulators and enhancers.

The first mathematical criterion to identify global TFs, the κ-value, was reassessed on B. subtilis and confirmed its high predictive power by identifying all the previously reported, plus three potential, master regulators and eight sigma factors.

However, in both cases one important outcome of direct-vs-indirect interaction analysis resulted, i.e. the presence (or better the visibility of the presence) of key players: in one case transcription factor genes acting as master regulators and in the other researchers identified as group leaders.

We construct a meiotic initiation pathway using an ODE-based model that includes regulation of Ime1, the master regulator, and five other early-meiotic proteins.

We only found one case of homology between the master regulator and its targets (LexA,UmuD).

Regulatory relationships were then established between the master regulator and its predicted targets in IPA.

AMPK is a master regulator and a major cellular energy sensor of metabolic homeostasis.

We previously showed that Mdm2, a master regulator and inhibitor of p53, is a cleavage target of Caspase-2.