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The identification of a master regulator that regulates the entire ligninolytic system in white-rot fungi could be used as a target for breeding a high lignin-degrading strain and for furthering our understanding of the lignin-degradation system in these fungi.
PPAR-γ is involved in the regulation of genes controlling lipid uptake and is also a "master" regulator that triggers the complete process of adipogenesis [ 15].
CTCF is a master regulator that plays important roles in genome architecture and gene expression.
One possibility is the presence of yet another master regulator that compensates for the loss of FoxM1.
Our findings, when taken together, indicate that SALL4 is a master regulator that controls its own expression and the expression of OCT4.
Chromatin packages all genomic DNA in eukaryotic cells and functions as a master regulator that governs gene transcriptional activation and silencing.
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Ecdysone (E) and juvenile hormone (JH) are endocrine master regulators that often interact to regulate many aspects of insect development and physiology; both hormones are known to respond to nutritional status and insulin/IGF-1 like signaling (IIS) [ 8- 10].
What emerges is a relatively small core of master regulators that are required for successful reprogramming of a differentiated cell into a cell exhibiting stem cell like properties.
Genome-wide trans-eQTL analyses may identify more master regulators that function to control several components of a single pathway.
In this setting, strong associations are thought to represent master regulators that exert broad, but potentially weak, effects in the regulatory network.
It will also be important to elucidate the crosstalk between signalling pathways and identify master regulators that are active nodes during different stressing conditions.
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