In mice, foxi1 has been reported to function as a master regulator in regulating differentiation of FORE cells in the inner ear [3] and intercalated cells in the urinary system [25].
This work is the first large-scale study attempting to identify the genetic networks regulated by RUNX1, a master regulator in the development of the hematopoietic system and leukemia.
As hypothesized, c-Myc is the master regulator in the USP2a-driven γ-GCS regulation, as c-Myc silencing reverts the expression and activity stimulation elicited by USP2aWT (Supplementary Figures 6a d).
Although we could not discern a single functional class of genes trans-regulated by Rgs7, our data suggests that Rgs7 is a master regulator in this region controlling other genes encoded in Qrr1 in trans (Table S1).
Given that NFκB is a master regulator in the immune system [ 23, 71, 77], RhoGTPases may, through NFκB, regulate many aspects of immunity, in particular innate immunity.
Phytohormone auxin is a master regulator in plant growth and development.
TBR1 is necessary for neuronal differentiation of NPCs and is a potential master regulator in autism spectrum disorders48.
Chuang, H. C., Huang, T. N. & Hsueh, Y. P. T-Brain-1 a poT-Brain-1 ater T-Brain-1 an autism spotentialisorders.
Villeda said the anti-ageing effect was linked to a protein called Creb that acts like a master regulator in the brain.
The nuclear factor-E2-related factor 2 (NRF2) serves as a master regulator in cellular defense against oxidative stress and chemical detoxification.
