Sentence examples for master regulator and from inspiring English sources

We construct a meiotic initiation pathway using an ODE-based model that includes regulation of Ime1, the master regulator, and five other early-meiotic proteins.

From Figure 6 it was apparent that most collaborative regulations in our network have a master regulator, and this is the regulator typically identified by the co-expression network.

Mesp1 directly and/or indirectly regulated the expression of the majority of key cardiovascular transcription factors including Hand2, Myocardin, Nkx2-5, Gata4, Mef2c, Foxc1, and Foxc2, thus acting as a master regulator and the earliest marker of cardiovascular development in vertebrates and cardiovascular differentiation in mammalian pluripotent stem cells.

We only found one case of homology between the master regulator and its targets (LexA,UmuD).

The master regulator and tumor suppressor p53, which is one of the most important and studied proteins in the cancer field, is a tetrameric (dimer of dimer proteins) sequence-specific transcription factor able to bind to two copies of a decameric sequence with the RRRCWWGYYY consensus (where R stands for a purine, W for A/T and Y for a pyrimidine) [19].

By using single and double H. pylori mutants and the corresponding purified enzymes, the bacterial vacuolating toxin A (VacA) and γ-glutamyl transpeptidase (GGT) plus lipopolysaccharide (LPS) tested positive for their ability to regulate miR-155 and Foxp3 expression in human lymphocytes; the latter being considered as the master regulator and marker of regulatory T cells.

Many other TFs are further downstream of the NAC and MYB domain master regulators, and form the hierarchical and non-hierarchical regulation networks.

Multitherapy resistance was associated with a semi-stable cell state that was characterized by an altered DNA methylation pattern at promoter regions of mesenchymal master regulators and enhancers.

Furthermore, Tcf3 co-occupies a large number of promoters with the master regulators Oct4 and Nanog in mESCs [28]; and depletion of Tcf3 causes increased expression of master regulators and delayed differentiation [28], [29].

The first group is activated by the master regulators and is essential for the establishment and maintenance of pluripotency of ESCs.

These master regulators and their genomic neighborhoods may be the epicenter of different clinical properties of GIST and LMS.