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In CoCl2 treated cells the YY1 transcription factor was identified as a potential master regulating factor with GSEA.
Ankyrin G is the master regulating protein for AIS assembly and recruits other molecular components such as βIV spectrin and sodium channels to the AIS (Zhou et al., 1998; Jenkins and Bennett, 2001; Yang et al., 2007).
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The identification of a master regulator that regulates the entire ligninolytic system in white-rot fungi could be used as a target for breeding a high lignin-degrading strain and for furthering our understanding of the lignin-degradation system in these fungi.
TFEB is a master gene regulating the autophagy-lysosome pathway.
AMPK acts as a metabolic master switch regulating several intracellular systems fatty acid metabolism, protein synthesis and cell growth [ 22– 22].
Mat a-1 is one of the master genes regulating fertilization in mat a strains of Neurospora, as well as in other species [ 14].
Here we propose that GluD2 serves as a master switch, regulating LTD inducibility in the cerebellum by coordinating unique interactions between GluA2's 2 phosphorylation sites (Fig. 1).
Recent molecular and genetic studies have revealed that a subgroup of Arabidopsis NAC domain transcription factors (SND1, NST1, VND6, 7) are master switches regulating a cascade of downstream transcription factors, leading to activation of secondary wall biosynthesis [ 81- 86].
Molecular and genetic studies in the model plant, Arabidopsis thaliana, revealed that a group of secondary wall-associated NAC domain (SWN) transcription factors are master switches regulating a cascade of down-stream transcription factors, such as MYB transcription factors that leads to the activation of the secondary wall biosynthetic program [ 62, 63].
Despite broad knowledge of the genes positively and negatively regulated by master regulators, the intricate networks of gene transcription regulation in response to stressors are still not completely understood.
This strategy could also be applied to TFs associated with the signalling pathways controlled by master regulators to up-regulate the expression of certain genes.
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