Sentence examples for master kinase that from inspiring English sources
PI3K is a master kinase that catalyzes the phosphorylation of PtdIns(4,5 P2 to produce PtdIns 3,4,5 P3.
Moreover, phosphorylation of the activating Thr172 site on AMPK, a master kinase that controls cellular energy metabolism, was not changed in the knockin animals.
Recently, it has been reported that NFV induces anchorage-independent growth and a G1 cell cycle arrest in melanoma cells by decreased activity of CDK2, a master kinase that regulates G1-S progression [ 32].
In the context of the AMPK family the obvious candidate is LKB1, a "master kinase" that phosphorylates and activates multiple AMPK family kinases 21.
Lkb1 (also known as Stk11) knockout mice have been important in the evaluation of the metabolic role of the AMPK-related kinases, since it is a master kinase that activates the majority of the members of this subfamily [ 3].
The convenience of having to knock out only a single gene is counterbalanced, however, by the status of LKB1 as a master upstream kinase that also acts upstream of the ARKs: thus, a phenotype caused by a tissue-specific LKB1 knockout cannot simply be ascribed to loss of AMPK activation without additional evidence.
The LKB1 tumour suppressor is a serine/threonine kinase that functions as master regulator of cell growth, metabolism, survival and polarity.
AMPK is a phylogenetically conserved serine/threonine kinase that functions as a master metabolic regulator.
AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that acts as a master sensor of cellular energy balance in mammalian cells by regulating glucose and lipid metabolism [ 34].
ATM, the gene that is mutated in the hereditary disease ataxia-telangiectasia, codes for a protein kinase that acts as a master regulator of cellular responses to DNA double-strand breaks (Bakkenist and Kastan, 2003).
The AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that has emerged as a master sensor of cellular energy balance in mammalian cells.
