Sentence examples for master gene that from inspiring English sources

I asked Dr. Guarente what REALLY was at the root of the effects of this master gene that controls longevity (called SIRT-1 in humans).

TFEB is a master gene that regulates autophagy and lysosomal gene expression.

Atoh1 acts as a master gene that instructs cell fate commitment in secretory lineages and acts as a brake on oncogenic process throughout the whole intestinal tract.

We investigated the therapeutic potential of liver-directed gene transfer of transcription factor EB (TFEB), a master gene that regulates lysosomal function and autophagy, in PiZ transgenic mice, recapitulating the human hepatic disease.

Transcription factor EB TFEBB) is a master gene that regulates the number and function of lysosomes and autophagy (Medina et al, 2011; Sardiello et al, 2009; Settembre et al, 2011).

Using a novel gene therapy approach, Pastore et al. studied the effect of transcription factor EB (TFEB), a master gene that regulates autophagy and lysosomal gene expression (Pastore et al., 2013).

These clusters contain the master genes that control the overall body plan of a developing embryo.

Instead, blindness seems to be caused by mutations on a reduced number of master genes that control eye development The energy needed to make an eye, which is basically a globule of protein that encapsulates water, may be less than what is needed to make the plug of fat and bone in blind cave fish.

Since our data indicate that RNase L regulates master genes that control pluripotency (Stat3, Fzd7), myogenesis (MyoD, Stat3, Hdac5) and adipogenesis (Chop-10/Ddit3, Aebp1), we decided to differentiate C2-RNase L cells after induction of RNase L during the multipotency phase.

The rationale underlying this approach is that despite the obvious molecular complexity of the cell migration process, there might be "master genes" that could induce migratory features in a stationary cell.

Indeed, cyclin D1 represses the activity of nuclear respiratory factor-1 (NRF-1), one of the master genes that drive the expression of several mitochondrial genes.