They both screened for a combination of factors that are both necessary and essential for reprogramming fibroblasts into pluripotency, in contrast to the identification of a single master factor in earlier transdifferentiation and reprogramming studies [6].
Therefore, ABF2/AREB1, ABF3 and ABF4/AREB2 are master transcription factors in ABA signalling and play cooperative roles in drought and salt stress tolerance (Kang et al. 2002; Kim et al. 2004b; Fujita et al. 2005; Furihata et al. 2006; Yoshida et al. 2010).
To conclude, we have demonstrated that ALK+ALCL aberrantly expresses Sox2, one of the master transcriptional factors in ESCs.
CD4+ helper T cells differentiate into specialized subsets, which attain restricted patterns of cytokine secretion and specific expression of master transcription factors in response to pathogens [ 16].
For example, osteoblastic differentiation of MSCs is controlled by Runx2, Osterix and Dlx5, whereas PPAR γ and C/EBP α are the master transcription factors in adipocyte commitment.
A much more thorough understanding of the mechanism of master transcriptional factors in mandibular chondrogenesis lay the important foundation for the application of targeted interventions at the molecular level, endogenous tissue engineering, and cell-based therapies in mandibular anomalies.
Western blot analysis showed that NFATc1, the master transcription factor in osteoclast differentiation, was significantly downregulated in ZAS3−/− bone marrow stromal cells comparing to controls (Fig. 2K).
ACC1 and FAS are target genes of SREBP-1c, which is the master transcription factor in hepatic lipogenesis [ 30].
25 Long-term treatment of MSCs with TGF-β1 induces the expression of myocardin, a master transcriptional factor in SMCs (unpublished observation).
Runx2 is the master transcription factor in bone formation, and several reports indicated that it is regulated by TGF-β1 and BMP-2.
