Sentence examples for master cell cycle from inspiring English sources

To determine if pathways affected by these NETs involved the p53 master cell cycle regulator, these eight NETs were retested in p53−/− cells.

In the case of Gram negative and alpha-proteobacterium C. crescentus, the ClpXP protease regulates the transcription of cell division genes via degradation of the master cell cycle regulator, CtrA [11], [18].

As FoxM1 is a master cell cycle gene for many cell cycle proteins, we deleted FoxM1 from DP thymocytes by crossing floxed FoxM1 mice [23] to two different T cell specific Cre transgenic mice (lck-Cre and CD4-Cre) [24], [25].

Given the role of FoxM1 as a master cell cycle regulator in other cell types [23], [28], [33], including mature T cells (this report), it is surprising to see that cyclin B1 is the only protein whose expression is being affected in FoxM1-deficient DP thymocytes.

Notably, genes associated with the cell cycle and proliferation, including the master cell cycle regulatory genes E2F1 and p21, were over-represented.

For example, CtrA is a master cell cycle response regulator that contributes to swarmer cell differentiation in Caulobactor crescentus [ 57, 58].

Blr2191 is a ChpT histidine phosphotransferase, well characterized in Caulobacter crescentus, a model organism in cell-cycle studies [ 101]; in this bacterium, the protein controls, via phosphorylation, the activity of the master cell-cycle regulator CtrA [ 102, 103].

Target prediction showed that BMI1, a transcription factor necessary for hematopoietic stem cell (HSC) and leukemia stem-cell self-renewal (27, 28), is the putative target of both miR-27a and miR-128b, while E2F1, a master cell-cycle regulator, is the target of miR-223 (29).

The master cell-cycle regulators Fkh1 and Fkh2 have many interaction partners; the cell-cycle regulators Mcm1 and Yox1 are connected; the RP regulators Fhl1, Rap1, and Sfp1 are connected; heme-activator proteins Hap1, Hap2, Hap3, and Hap4 are connected; sulfur amino acid biosynthesis regulators Met4 and Met32 are connected; and glycolysis regulators Gcr1 and Gcr2 are connected.

Altogether, these results demonstrate that vitamin D hampers proliferation by targeting several key masters of cell cycle progression.

In cancer cells, MELK forms a protein complex with the transcription factor/oncogene FOXM1, a master regulator for cell cycle progression [35].