Sentence examples for massively parallel instruments from inspiring English sources

Specifically, it has been shown that when whole-genome shotgun sequencing is performed on massively parallel instruments, the number of sequence reads that align to a position in the genome is proportional to the copy number at that position [9].

The pace of cost reduction accelerated even further with the launch and subsequent evolution of the massively parallel sequencing instruments seen in recent years.

Existing massively parallel sequencing instruments, such as the Illumina HiSeq 2500, produce accurate short reads typically up to ~250bp in length.

Recent development of massively parallel sequencing instruments (Roche 454, Illumina/Solexa, and AB SOLiD) makes it possible to resequence genes of interest in a mutagenized population with relatively low cost [ 27, 28].

In essence, RNA (converted into cDNA) is sequenced in massively parallel sequencing instruments such that the number of times a sequence is represented in the output sequence data represents its relative abundance in the input RNA - in other words its expression level.

Sequencing targeted regions on massively parallel-sequencing instruments requires methods for concomitant enrichment of the templates to be sequenced.

Over time, our genomic characterization of hematologic malignancies has moved beyond the resolution of the microscope to that of individual nucleotides in the analysis of whole-genome sequencing (WGS) data using state-of-the-art massively parallel sequencing (MPS) instruments and algorithmic analyses of the resulting data.

The problem has been further exacerbated by the next generation (massively parallel) DNA sequencing instruments that can sequence up to one billion bases in a single day at low cost [36].

Massively parallel DNA sequencing instruments are enabling the decoding of whole genomes at significantly lower cost and higher throughput than classical Sanger technology.

The commercial launch of massively parallel DNA sequencing instruments in 2005 initiated a paradigm shift powered by new DNA sequencing techniques that inspired researchers to address bolder questions in genome-wide experiments.

A variety of techniques that specifically target human gene sequences for differential capture from a genomic sample, coupled with next-generation, massively parallel DNA sequencing instruments, is rapidly supplanting the combination of polymerase chain reaction and capillary sequencing to discover coding variants in medically relevant samples.