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The massive virus replication across all organs was probably associated with organ dysfunction and multisystem failure already shown for VARV infections in cynomolgus macaques [30].
This is most probably a reflection of the abrupt and massive virus replication in the lungs following intratracheal inoculation, which in turn induces an overwhelming and simultaneous production of several cytokines.
In addition, influenza virus viremias are often associated with ARDS caused by massive virus replication in the lungs during infection, but our patient had no pulmonary infection.
See related research by Bermejo-Martin et al., http://ccforum.com/content/13/6/R201, related commentary by Fernández de Castro et al., http://ccforum.com/content/14/1/115 and related letter by Krstíc, http://ccforum.com/content/14/2/410 Uncomplicated influenza in humans is characterized by massive virus replication in respiratory epithelial cells, inflammation and an abrupt onset.
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The loss of FSFs was abrupt and massive for viruses.
The announcement is timed just one week after security researchers discovered Flame, a massive, data-mining virus, had been spying on computers in the Middle East– predominantly in Iran– for at least the last four years.
One could argue the fact that infected poultry flocks produce massive amounts of virus, which supports the view that infection in wild birds is mostly seeded from poultry.
Mild multifocal necrosis of hepatocytes and a lymphocytic infiltrate were also observed, and massive amounts of virus antigen were distributed within the sinusoidal endothelium and in necrotic hepatocytes within the liver.
As an emergent topological property of HIN, we also highlighted a massive attack of viruses on bridging proteins.
Investigations of viral quasi-species during a massive avian influenza A/H7N7 virus outbreak in the Netherlands indicated that viruses with human adaptation markers, including HA mutations that alter receptor specificity and mutations in polymerase proteins that increase polymerase activity like E627K in PB2, emerged rapidly in poultry (55 57).
In contrast, IDC16 did not prevent massive spreading of the virus when applied with the highest MOI, with a 35% inhibition of virus infection at the MOI of 10 FFU/cell (Fig. 1B).
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