Sentence examples for massive ups and from inspiring English sources

"There were massive ups and downs".

That's racing, I've known from over the years that it can be massive ups and massive downs".

*** "There are massive ups and downs," says Peter Johnson, 37, who is trembling and on the brink of tears when I first encounter him just before he goes into court.

3.31pm GMT 42 min Toomua spots a huge gap on the England left and sends up a massive up-and-under.

"Union is massive up in Scotland and, to be playing here in Cumbria with the first and second games both sell-outs, we're getting really good support down here," he said.

It showed a massive up-regulation of cellulolytic and hemicellulolytic CAZymes, and ribosomal proteins (Table  2).

Using an inducible adipocyte-specific VEGF-A overexpression model, Sun et al. demonstrated that the local up-regulation of VEGF-A in adipocytes improved vascularization and led to the browning of WAT, with massive up-regulation of UCP1 and PGC-1α (Sun et al. 2012).

"The two Scotland-England games I've been involved in had a massive build-up and a massive emotional experience.

The synergy between TNF-α and IFN-β results in a more pronounced IFN and pro-inflammatory cytokine response after H5N1 infection, and the massive up-regulation of these cytokines tips the balance in favour of a hyper-inflammatory response.

A common theme across many of these studies is the massive up-regulation of inflammation- and innate immunity-related genes in patients with sepsis and septic shock.

It is now acknowledged that direct cellular contact with stimulated T cells induces the massive up-regulation of IL-1 and TNF in human monocytes/macrophages [3] [5].