Erlotinib and chemotherapy inhibited tumor growth rate to a similar extent during drug administration, although chemotherapy determined a massive systemic toxicity in a fraction of animals, whereas erlotinib was highly tolerable.
While the list of medications with theoretical toxicity is massive (77), a few agents of clinical importance will be discussed here.
In the 1990s, third-generation chemotherapeutic agents, including paclitaxel, docetaxel, vinorelbine, gemcitabine and irinotecan, were shown to have higher response rates often coupled with fewer adverse effects (no renal toxicity, no massive dehydration, less emesis, etc).
The experimental results reveal the potential of this technology for future implementation as an inexpensive massive method for rapid environmental toxicity detection.
In order to assess and predict an important source of toxicity of Taihu the massive occurrence of blue-green algae the stoichiometric lake model "StoLaM" is further developed to simulate algae growth.
Besides this massive diversity regarding the mechanisms of toxicity among NP, species and ecosystems, some more general questions attracted attention among researchers, namely the relevance of ions released (dissolved) from NP for NP-induced effects.
Administration of alpha-naphthylthiourea (ANTU) to rats causes damage to pulmonary endothelial cells and possibly mesothelial lining cells that together may account for the massive pleural effusion characteristic of thiourea toxicity.
In addition, the recent discussion about the potential toxicity of nanoparticles and their massive use places them in the spotlight.
This massive aggregation can contribute to reduce LPS toxicity, through the inhibition of the interaction of LPS with its receptor [30], [31] and by facilitating the phagocytosis of the aggregates by macrophages [32].
