If they only tested it on elephants, then its one massive side-effect, that it turned you into an elephant, could easily have been missed.
As a result of this, a large increase in tumor drug concentrations (tenfold or higher) could be achieved relative to administration of the same dose of free drug, (Maeda et al. 2000) thereby decreasing the massive systemic side effects of conventional chemotherapy.
Furthermore, their presence in GM corn means that truly massive unexpected side effects have taken place in the plants' biochemistry.
There are many side effects after massive dose of glucocorticoid treatment such as increased susceptibility to infection, gastroinstestinal ulcer, diabetes mellitus, and mental disorder.
On the other hand, massive volcanic eruptions, which are "side effects" of plate tectonics, have caused (or significantly contributed to) several mass extinctions during Earth's history.
One of the side effects of the massive wave of condo developments and gentrification that Toronto has experienced over the past decade is that there just aren't many big empty warehouse spaces left downtown that are suitable for all-night parties.
In addition, stimulation of CD95 could never be used therapeutically because of major side effects such as massive apoptosis induction in the liver.
That massive fossil fuel consumption produces some nasty side effects, including climate change, acidified oceans, and oil spills.
In order to try and assuage fears about both Vioxx and Arcoxia, Merck has started massive outcomes trials, specifically looking for cardiac side effects.
