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Future implementation and development of massive sequencing applications and high density microarrays will fill the gap of genomic/transcriptomic information which is actually the major limitation in the use of Mytilus galloprovincialis as a model organism, thus providing more robust assessments into an ecologically relevant species ubiquitously present along the coastal marine environments.
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However in the immediate future, with the development of massive sequencing systems for application at clinical diagnosis, it will be necessary to have clinical criteria to guide studies.
One of the most interesting applications of massive sequencing is the large-scale discovery of genetic variants that can be converted into genetic markers, mainly microsatellites or Simple Sequence Repeats (SSR) and Single Nucleotide Polymorphisms (SNP) [ 19].
Genome sequences are being obtained at an increased rate with the systematic application of massive sequencing techniques.
We expect that PHLAT, as a useful method for high resolution HLA typing, help leverage the application of the massive sequencing data in the existing and future human genetics studies.
The increasing availability of genome sequences through the application of next-generation massive sequencing technologies has allowed the study of genomic polymorphisms at both the interspecific and intraspecific levels, thus helping to understand how species adapt to changing environments through genome variability.
Plant genome sequencing – applications for crop improvement.
Next Generation Genome sequencing techniques became affordable for massive sequencing efforts devoted to clinical characterization of human diseases.
Altmüller, J., Budde, B. S. & Nürnberg, P. Enrichment of target sequences for next-generation sequencing applications in research and diagnostics.
However, it requires massive sequencing effort with considerable costs.
Massive sequencing data can be overwhelming to examine.
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